METABOLISM AND MUTAGENICITY OF 2-ACYLAMINOFLUORENES AND RELATED COMPOUNDS
作者： Snorri S. Thorgeirsson , Peter J. Wirth , Wendel L. Nelson
DOI: 10.1016/B978-0-08-021523-5.50080-8
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摘要: ABSTRACT There is a strong association between aromatic hydrocarbon responsiveness and N-hydroxylation of phenacetin, acetanilide, p-chloroacetanilide in the livers from progeny appropriate backcrosses intercross involving B6 D2 mice. Mutagenic activity Salmonella test system several 2-acylaminofluorenes were compared using S-9 liver fractions Pretreatment mice with 3-MC increased mutagenic all analogs fraction. No increase found fraction after pretreatment, indicating that correlates N-hydroxylase activity. ANF, an inhibitor 2-AAF vitro, inhibits these first step activation N-acylaminofluorenes into mutagens.
sci-hub.st 参考文章(7)
Wendel L. Nelson, Snorri S. Thorgeirsson, Structural requirements for mutagenic activity of 2-acylaminofluorenes in the Salmonella test system Biochemical and Biophysical Research Communications. ,vol. 71, pp. 1201- 1206 ,(1976) , 10.1016/0006-291X(76)90781-6
Steven A. Atlas, Daniel W. Nebert, Genetic association of increases in naphthalene, acetanilide, and biphenyl hydroxylations with inducible aryl hydrocarbon hydroxylase in mice Archives of Biochemistry and Biophysics. ,vol. 175, pp. 495- 506 ,(1976) , 10.1016/0003-9861(76)90537-3
Snorri S. Thorgeirsson, Wendel L. Nelson, Separation and quantitative determination of 2-acetyl-aminofluorene and its hydroxylated metabolites by high pressure liquid chromatography Analytical Biochemistry. ,vol. 75, pp. 122- 128 ,(1976) , 10.1016/0003-2697(76)90062-2
B. N. Ames, F. D. Lee, W. E. Durston, An improved bacterial test system for the detection and classification of mutagens and carcinogens Proceedings of the National Academy of Sciences of the United States of America. ,vol. 70, pp. 782- 786 ,(1973) , 10.1073/PNAS.70.3.782
Snorri S. Thorgeirsson, Daniel W. Nebert, James S. Felton, Genetic differences in the aromatic hydrocarbon-inducible n-hydroxylation of 2-acetylaminofluorene and acetaminophen-produced hepatotoxicity in mice. Molecular Pharmacology. ,vol. 11, pp. 159- 165 ,(1975)
Snorri S. Thorgeirsson, Daniel W. Nebert, James S. Felton, Genetic differences in 2-acetylaminofluorene mutagenicity in vitro associated with mouse hepatic aryl hydrocarbon hydroxylase activity induced by polycyclic aromatic compounds. Molecular Pharmacology. ,vol. 12, pp. 225- 233 ,(1976)
Daniel W. Nebert, Joseph R. Robinson, Genetic expression of aryl hydrocarbon hydroxylase induction. Presence or absence of association with zoxazolamine, diphenylhydantoin, and hexobarbital metabolism. Molecular Pharmacology. ,vol. 10, pp. 484- 493 ,(1974)