Prognostic implication of EGFR gene mutations and histological classification in patients with resected stage I lung adenocarcinoma.

摘要: Introduction The prognostic value of epidermal growth factor receptor (EGFR) mutations and the correlation between EGFR new International Association for Study Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) histological classification remain controversial. The current study aimed to investigate pure role in treatment-naive patients with resected stage I lung adenocarcinoma. Methods We retrospectively reviewed 373 pulmonary non-small-cell cancer who underwent complete surgical resection January 2010 May 2014. tumors were classified according IASLC/ATS/ERS criteria. mutation status was determined by established methods. Results A total 120 included analysis; 87 had 33 wild-type tumors. More low- intermediate-grade mutations, nearly half high-grade (75.7% versus 46.2%, p = 0.041). Patients low-grade significantly greater median disease-free survival (DFS) (76.8 13 months, < 0.0001) better overall (OS) (median OS not reached, 0.0003) than those intermediate- Tumor recurrence 41.4% 30.3% mutant patients. 5-years rate 54% 71.2%. Multivariate analysis revealed that pathologic independent predictors both DFS OS. no implications. Conclusion Low grade IA adenocarcinomas independently predict frequently seen histologically but a factor.