Adjuvant treatment of colorectal cancer: towards tumor-specific immunotherapies.

摘要: Colorectal cancer is one of the leading causes cancer-related mortality. After a series clinical trials, adjuvant 5-FU based chemotherapy has established definitive role in management stage III colon cancer. The precise for II disease remains under investigation and less toxic treatment modalities like active specific immunotherapy have emerged as potentially attractive alternatives. It most likely that will move towards more tumor-specific immunotherapies using antibody- or vaccination-based strategies. Phase II/III trials investigating these different colorectal are reviewed.