Pan-cancer patterns of DNA methylation

摘要: The comparison of DNA methylation patterns across cancer types (pan-cancer methylome analyses) has revealed distinct subgroups tumors that share similar patterns. Integration these data with the wealth information derived from genome profiling studies performed by large international consortia provided novel insights into cellular aberrations contribute to development. There is evidence genetic mutations in epigenetic regulators (such as DNMT3, IDH1/2 or H3.3) mediate patterns, although a unifying molecular mechanism underlying global alterations largely been elusive. Knowledge gained pan-cancer analyses will aid development diagnostic and prognostic biomarkers, improve patient stratification discovery druggable targets for therapy, generate hypotheses innovative clinical trial designs based on rather than subtypes. In this review, we discuss recent advances tumor genomes aberrant integration data, highlight potential mechanisms leading different subgroups, show how can be used basic research translational applications. A remaining challenge experimentally prove functional link between observed associated aberrations, their relevance cancer.