Clinical implications of TPO and AOX1 in pediatric papillary thyroid carcinoma.

摘要: Background Thyroid carcinoma is a common pediatric head and neck cancer, of which papillary thyroid cancer (PTC) the most type. Previously, we found that peroxidase (TPO) aldehyde oxidase 1 (AOX1) were differentially expressed in PTC. This study explored clinical importance TPO AOX1 diagnosis prognosis PTC children. Methods Both expression analyzed using datasets from Gene Expression Omnibus (GEO). protein levels plasma patients with non-tumor controls detected via enzyme-linked immunosorbent assay (ELISA). The diagnostic accuracy was assessed receiver operating characteristic (ROC) curve analysis. association between gene patient survival Kaplan-Meier plotter online database. Results results revealed significantly downregulated four independent (GSE33630, GSE27155, GSE3678, GSE3467). blood decreased Quantitative analysis demonstrated had satisfactory predictive performance ability to discriminate healthy samples. Prognostic low markedly associated poor Conclusions In summary, these implied could serve as novel biomarkers for