Sequential changes in serum thyroid peroxidase following radioiodine therapy of patients with differentiated thyroid carcinoma.

摘要: To determine the detectability and time course of serum thyroid peroxidase (TPO) levels before 1, 2, 4, 6 months after 131I administration, we evaluated TPO in 13 selected patients with differentiated carcinoma (DTC) whose sera did not contain antimicrosomal or antithyroglobulin (Tg) antibodies. All received therapy 8 weeks surgery for ablation postsurgical remnant. Serum samples were also collected from 10 normal subjects. Measurement was carried out by using a new commercially available immunoluminometric assay sensitivity 30 pg/mL. Tg measured RIA 2.6 micrograms/L administration. In all patients, standard total body scan obtained undetectable However, became detectable DTC during study, whereas rescans either negative positive appeared to be related radioiodine dose given, histology tumor, residual volume, TSH levels, age patients. significant correlation present between administration (r = -0.82, P < 0.001). Six had increased 1 month tended decrease follow-up most (7 10) rescan. 3 rescans, increase follow-up. Patients values overlapping range seen thus demonstrating inability as useful marker following DTC. We found no thereby excluding cancer. Our results suggest that TPO, unlike Tg, does appear