Methods of modulating various biomarkers with curaxins
作者： Ivan Bespalov
DOI:
关键词:
摘要: The present invention relates to improved methods for, treating cancer, including, for example, cancer characterized by reduced levels of p53 and/or activity, with agents that can modulate and restore its genomic protection effect. also provides predicting patient response various agents, including curaxins (e.g. Curaxin 137) monitoring one or more biomarkers FACT a NF-kB-responsive marker) directing care accordingly.
lens.org 参考文章(7)
H M-L Ball, T R Hupp, D Ziyaie, C A Purdie, N M Kernohan, A M Thompson, Differential p53 protein expression in breast cancer fine needle aspirates: the potential for in vivo monitoring British Journal of Cancer. ,vol. 85, pp. 1102- 1105 ,(2001) , 10.1054/BJOC.2001.2064
Katerina Gurova, Andrei Gudkov, Curaxins for use in treating breast cancer and method for identifying patients likely to respond ,(2013)
Andrei Purmal, Katerina Gurova, Andrei Gudkov, Leonid Brodsky, John Tucker, Sergey Sviridov, Catherine Burkhart, Carbazole compounds and therapeutic uses of the compounds ,(2009)
Mark T Boyd, Nikolina Vlatkovic, p53: a molecular marker for the detection of cancer. Expert Opinion on Medical Diagnostics. ,vol. 2, pp. 1013- 1024 ,(2008) , 10.1517/17530059.2.9.1013
Xiaoyang Wu, Yunliang Wang, Hongwei Wang, Qiang Wang, Lin Wang, Jingcheng Miao, Fengmei Cui, Jinzhi Wang, Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Current Therapeutic Research-clinical and Experimental. ,vol. 73, pp. 52- 64 ,(2012) , 10.1016/J.CURTHERES.2012.02.003
K. V. Gurova, J. E. Hill, C. Guo, A. Prokvolit, L. G. Burdelya, E. Samoylova, A. V. Khodyakova, R. Ganapathi, M. Ganapathi, N. D. Tararova, D. Bosykh, D. Lvovskiy, T. R. Webb, G. R. Stark, A. V. Gudkov, Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 17448- 17453 ,(2005) , 10.1073/PNAS.0508888102
A. V. Gasparian, C. A. Burkhart, A. A. Purmal, L. Brodsky, M. Pal, M. Saranadasa, D. A. Bosykh, M. Commane, O. A. Guryanova, S. Pal, A. Safina, S. Sviridov, I. E. Koman, J. Veith, A. A. Komar, A. V. Gudkov, K. V. Gurova, Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT. Science Translational Medicine. ,vol. 3, ,(2011) , 10.1126/SCITRANSLMED.3002530