Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901.
作者： Xiaoyang Wu , Yunliang Wang , Hongwei Wang , Qiang Wang , Lin Wang
DOI: 10.1016/J.CURTHERES.2012.02.003
关键词:
摘要: Background Quinacrine (QC), an antimalarial drug, has been shown to possess anticancer effect both in vitro (cancer cell lines) and vivo (mouse models). In the cancer cells, QC can simultaneously suppress nuclear factor-κB activate p53 signaling, which results induction of apoptosis these cells. However, experimental come from a few limited lines, detailed mechanisms remain unknown.
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