Neurodevelopmental risks for bipolar disorder

摘要: Neurodevelopmental risks for Bipolar Disorder David Freedman This dissertation aims to add the growing literature on and mechanisms in early life that may be associated with later bipolar disorder (BP), expanding understanding of when why divergences from typical developmental course occur BP, if they do. To do so, it utilizes prospectively obtained, serologically documented prenatal biomarkers clinically perinatal risk factors, as well premorbid measures neurocognitive functioning, a well-defined birth cohort followed up BP. offers unique opportunity test some evidence whether BP is neurodevelopmental illness. The first paper systematic review hypothesis focuses three time points: exposures, prodromal symptom development, functioning prior onset. second two specific putative factors BP: T. gondii oxytocin induce labor. third assesses cognition, using both case-control study full assess potential cognitive impairment reflects mediator or endophenotype Taken whole, findings suggest support indicate potentially