Polymorphism at the mucin-like protocadherin gene influences susceptibility to gallstone disease

摘要: Abstract Background Gallstone disease (GSD) is a common that can be caused by environmental influences, genetic factors and their interactions. Mucin glycoproteins may one important factor for GSD. We conducted case–control study to investigate the relationship between mucin-like protocadherin (MUPCDH) gene polymorphisms Methods The included 452 GSD cases 491 healthy controls who had no evidence of gallstones ultrasound examination. Two tagging single nucleotide polymorphism (SNP) rs3758650 rs7932167, four non-synonymous SNPs rs34362213, rs2740375, rs7108757 rs2740379 were genotyped. effects evaluated using multivariate regression model. Results genotypes these all in Hardy–Weinberg equilibrium. Three (rs34362213, rs2740379) monomorphic. SNP analysis showed two (rs7932167 rs2740375) not associated with only association presence an odds ratio (OR) 1.59 (adjusted P = 0.013) AG genotype 5.82 P = 0.007) AA when compared reference GG genotype. haplotype three polymorphic GCA was significant p = 0.001) 1.41 other haplotypes. Conclusions MUPCDH considered marker predict symptomatic subjects. It importance patients risk frequently checked because they develop