Protein kinase C (PKC) isozyme-specific substrates and their design
作者： Jeong-Hun Kang , Riki Toita , Chan Woo Kim , Yoshiki Katayama
DOI: 10.1016/J.BIOTECHADV.2012.07.004
关键词:
摘要: Protein kinase C (PKC), a phospholipid-dependent serine/threonine kinase, appears to be involved in the signal transduction response many hormones and growth factors; there are 11 different PKC isozymes. Because isozymes directly and/or indirectly participate pathways of normal transformed cells through phosphorylation target proteins, it is critical understand diversity intracellular signaling regulated by each isozyme. Thus, isozyme-specific substrates useful characterization for Consensus sequences sequence information obtained from proteins very important design peptide substrates. Moreover, computational prediction programs sites using library aid fast Although large number synthetic peptides PKCs known, only two (peptide 422-426 murine elongation factor-1α Alphatomega peptide) have been reported as This discussion will review literature concerning these native their design.
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