Risk factors associated with neuroendocrine tumors: A U.S.-based case-control study

摘要: Carcinoids are rare neuroendocrine tumors (NETs); however, their incidence has significantly increased in the United States over past 30 years. Little is known about epidemiology of these cancers and associated risk factors. We evaluated independent effects multiple factors with NETs arising at 5 disease sites (small intestine, stomach, lung, pancreas rectum). conducted a retrospective, hospital-based, case-control study involving 740 patients histologically confirmed 924 healthy controls. Information on different was collected, unconditional logistic regression analysis used to determine adjusted odds ratios (AORs) 95% confidence interval (CI) by maximum-likelihood method. Smoking alcohol consumption were not development either men or women. However, family history cancer significant factor for all NETs. A long-term diabetes mellitus gastric (AOR = 5.6; CI, 2.1-14.5), particularly women 8.4; 1.9-38.1). Diabetes modified among positive 52.2; 5.5-491.5). Our results suggest that may mostly explained genetic The both have greater susceptibility than men.