A 4-Week, Repeated, Intravenous Dose, Toxicity Test of Mountain Ginseng Pharmacopuncture in Sprague-Dawley Rats

摘要: Objectives Mountain ginseng pharmacopuncture (MGP) is a made by distilling extract from mountain cultivated or wild ginseng. This injected intravenously, which quick, lossless way of strongly tonifying Qi function. The present study was undertaken to evaluate 4-week, repeated, intravenous injection, toxicity test MGP in Sprague-Dawley (SD) rats. Methods Twenty male and female 6-week-old SD rats were used as subjects. We divided the into 4 groups: high-dosage (10 mL/kg), medium-dosage (5 low-dosage (2.5 mL/kg) control (normal saline) groups. normal saline intravenously caudal vein once daily for weeks. Clinical signs, body weights, food consumption monitored during observation period, hematology, serum biochemistry, organ weight, necropsy, histological examinations conducted observations had been completed. Results No mortality observed any groups period. changes due experimental regarding clinical consumption, weight necropsy. group. Conclusion During this rats, no toxic Thus, we suggest that high low doses 13-week, repeated should be 10 mL/kg 2.5 mL/kg, respectively.