Reduction of virus burden-induced splenectomy in patients with liver cirrhosis related to hepatitis C virus infection.
作者： Tetsuro Sekiguchi
关键词:
摘要: AIM: To examine the hepatitis C virus (HCV) levels and immunological markers in cirrhotic patients after splenectomy. METHODS: HCV RNA titers as well cellular humoral immune were determined 20 splenectomy 32 controls with an intact spleen. RESULTS: Serum lower splenectomized than (186 ± 225 × 103 copies/mL vs 541 ± 417 × 103 copies/mL, P < 0.01). was judged to have been spontaneously eradicated 4 patients, but none of controls. Natural killer cell activity higher (41.2 ± 19.3% 24.7 ± 15.3%, P < 0.01), natural negatively correlated except those serotype 2-related infection. The CD4/CD8 ratio significantly controls. CONCLUSION: findings suggest that may diminish burden infection at least part, through augmentation activity.
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