Study on anti-Oketsu activity of rhubarb II. Anti-allergic effects of stilbene components from Rhei undulati Rhizoma (dried rhizome of Rheum undulatum cultivated in Korea).
作者： Hideaki MATSUDA , Norimichi TOMOHIRO , Keiichiro HIRABA , Shoichi HARIMA , Sungkwon KO
DOI: 10.1248/BPB.24.264
关键词:
摘要: Methanol extract (RM-ext) obtained from the dried rhizome of Rheum undulatum was screened for activity in experimental models type I allergy. RM-ext exhibited inhibition on 48-h homologous passive cutaneous anaphylaxis (PCA) rats and an antigen-induced histamine release rat peritoneal mast cells. Among nine stilbenes isolated RM-ext, seven inhibited release. Rhapontigenin (compound 1), piceatannol (2) 3'-beta-D-glycoside (6) with oral administration showed PCA. Compounds 1 2 inhibitory effect sheep red blood cell-induced delayed-type hyper sensitivity (SRBC-DTH) IV allergic model. These results indicated that inhibits reactions these effects may be partially attributable to mentioned above.
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