Chondroitinase ABC promotes recovery of adaptive limb movements and enhances axonal growth caudal to a spinal hemisection.

摘要: A number of studies have shown that chondroitinase ABC (Ch9ase ABC) digestion inhibitory chondroitin sulfate glycosaminoglycans significantly enhances axonal growth and recovery in rodents following spinal cord injury (SCI). Further, our group has improved SCI the larger cat model. The purpose current study was to determine whether intraspinal delivery Ch9ase ABC, T10 hemisections adult cats, adaptive movement features during a skilled locomotor task and/or promotes plasticity supraspinal circuitry. Here, we show enhanced crossing peg walkway post-SCI ipsilateral hindlimb trajectories integration into functional forelimb–hindlimb coordination pattern. Recovery these complex movements associated with significant increases neurofilament immunoreactivity immediately below white ( p = 0.033) contralateral gray matter 0.003). rubrospinal tract is critical normal require accurate paw placements like those seen crossing. Rubrospinal connections were assessed Fluoro-Gold injections, caudal hemisection. Significantly more retrogradely labeled right (axotomized) red nucleus (RN) neurons ABC-treated (23%) compared control-treated cats (8%; 0.032) indicating RN had axons lesion level. Thus, SCI, may facilitate at level, enhance locomotion, affect circuitry known support behaviors cat.