Histaminergic Regulation of Blood–Brain Barrier Activity
作者： R. Ferreira , C. Ballerini , Maria Beatrice Passani , L. Bernardino
DOI: 10.1007/978-3-319-40308-3_8
关键词:
摘要: The histaminergic signalling system is very complex and several new roles for this small amine are still being explored. Histamine known its peripheral immune functions regulation of the central nervous (CNS). In present book chapter, we will detail on pathophysiological processes highlight role histamine blood–brain barrier (BBB) function, an important therapeutic target, albeit a common obstacle, treatment cerebrovascular diseases. Additionally, modulation BBB properties by may constitute means to deliver drugs more efficiently diseased brain tissue. particular, discuss key elements healthy disrupted BBB, namely, endothelial cells, astrocytes, microglia, pericytes smooth muscle cells. A deeper insight mechanisms underlying pathology be determinant develop most efficient platforms targeting repair ultimately CNS-related
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