In Vivo 31P-Nuclear Magnetic Resonance Study of the Response of a Murine Mammary Tumor to Different Doses of γ-Radiation
作者： W. M. M. J. Bovée , D. H. Rutgers , G. Los , P. E. Sijens , D. Seijkens
DOI:
关键词:
摘要: The response of the s.c. implanted murine mammary carcinoma NU-82 to 10 and 20 Gy γ-radiation was followed by in vivo 31P-nuclear magnetic resonance spectroscopy on 48 mice during a period 2 days. During first 8 h after dose Gy, ratio ATP/inorganic phosphate increases value 120 ± 15% (SE) control value. This rise is decrease 74 12% 47 h. However treatment with causes ATP/Pi gradually level 45 7% Histological investigations demonstrated that radiation-induced necrosis largely contributes this phenomenon. time observation irradiated tumors displayed no changes size intracellular pH. After as well phosphodiester decreased intensity. By extracts tumor, two phosphodiesters were identified, glycerophosphocholine glycerophosphoethanolamine.
aacrjournals.org参考文章(14)
William T. Evanochko, Ted T. Sakai, Thian C. Ng, N.Rama Krishna, Hyun Dju Kim, Robert B. Zeidler, Vithal K. Ghanta, R.Wallace Brockman, Lewis M. Schiffer, Paul.G. Braunschweiger, Jerry D. Glickson, NMR study of in vivo RIF-1 tumors: Analysis of perchloric acid extracts and identification of 1H, 31P and 13C resonances Biochimica et Biophysica Acta. ,vol. 805, pp. 104- 116 ,(1984) , 10.1016/0167-4889(84)90042-9
Robert C. Bohinski, Modern concepts in biochemistry ,(1976)
T H Koeze, P L Lantos, R A Iles, R E Gordon, In vivo nuclear magnetic resonance spectroscopy of a transplanted brain tumour. British Journal of Cancer. ,vol. 49, pp. 357- 361 ,(1984) , 10.1038/BJC.1984.56
T.C Ng, W.T Evanochko, R.N Hiramoto, V.K Ghanta, M.B Lilly, A.J Lawson, T.H Corbett, J.R Durant, J.D Glickson, 31P NMR spectroscopy of in vivo tumors Journal of Magnetic Resonance. ,vol. 49, pp. 271- 286 ,(1982) , 10.1016/0022-2364(82)90190-1
Mary J. Dorie, Robert F. Kallman, Reoxygenation in the RIF-1 tumor. International Journal of Radiation Oncology Biology Physics. ,vol. 10, pp. 687- 693 ,(1984) , 10.1016/0360-3016(84)90300-6
F. E. Evans, N. O. Kaplan, 31P nuclear magnetic resonance studies of HeLa cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 74, pp. 4909- 4913 ,(1977) , 10.1073/PNAS.74.11.4909
William T. Evanochko, Thian C. Ng, Jerry D. Glickson, John R. Durant, Thomas H. Corbett, Human tumors as examined by in vivo 31P NMR in athymic mice Biochemical and Biophysical Research Communications. ,vol. 109, pp. 1346- 1352 ,(1982) , 10.1016/0006-291X(82)91925-8
G. Navon, S. Ogawa, R. G. Shulman, T. Yamane, 31P nuclear magnetic resonance studies of Ehrlich ascites tumor cells. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 74, pp. 87- 91 ,(1977) , 10.1073/PNAS.74.1.87
W. T. Evanochko, T. C. Ng, M. B. Lilly, A. J. Lawson, T. H. Corbett, J. R. Durant, J. D. Glickson, In vivo31P NMR study of the metabolism of murine mammary 16/C adenocarcinoma and its response to chemotherapy, x-radiation, and hyperthermia Proceedings of the National Academy of Sciences of the United States of America. ,vol. 80, pp. 334- 338 ,(1983) , 10.1073/PNAS.80.2.334
Gil Navon, Robert G. Shulman, Tetsuo Yamane, T. Ross Eccleshall, Keng-Bon Lam, Jerald J. Baronofsky, Julius Marmur, Phosphorus-31 nuclear magnetic resonance studies of wild-type and glycolytic pathway mutants of Saccharomyces cerevisiae Biochemistry. ,vol. 18, pp. 4487- 4499 ,(1979) , 10.1021/BI00588A006