作者: David Dean , Nathan Cross , Davood Varghai , Nancy L. Oleinick , Chris A. Flask
DOI: 10.1007/978-3-540-68993-5_20
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摘要: We seek a noninvasive, functional, radiological imaging method to determine the specificity and sensitivity of an ablative treatment for deeply placed lesions that cannot be directly visualized, in our case phthalocyanine-4 photodynamic therapy (Pc 4-PDT) brain tumors. In preliminary study we had expected micro-positron emission tomography (μPET) would show dramatically reduced if not negligible 18F-FDG activity following Pc 4-PDT; however, has found statistically significant difference between tumors animals underwent 4-PDT those did not. While several magnetic resonance (MRI) pulse sequences also discriminate received treatment, dynamic contrast enhancement (DCE-MRI) was able undergone necrosis 4-PDT. expect addition therapeutic necrosis, it will possible utilize other techniques track apoptosis and/or autophagy treatments such as