Pulsatile machine perfusion with Vasosol solution improves early graft function after cadaveric renal transplantation.

摘要: Background. Cold storage is the most common method of preservation in renal transplantation, but pulsatile machine perfusion (MP) increasingly used for purposes ex vivo assessment and resuscitation high risk allografts. Vasosol (VSL) MP solution (MPS) (Pike Laboratories Inc, Eagle, PA) a novel perfusate with enhanced vasodilatory antioxidant capacity. We report our experience VSL Methods. Locally procured cadaver kidney pairs undergoing were randomized to or control (Belzer MPS; Trans-Med, Elk River, MN). En bloc was performed according standard procedures. Transplantation at 1 12 local transplant centers. Donor recipient data collected prospectively. Results. Data from 162 transplanted kidneys analyzed. A total 82 grafts perfused VSL, 80 solution. No organs lost secondary technique MP. There no difference donor age between groups. Kidneys exhibited significantly higher rates immediate function less delayed graft (12.2% vs. 21.2%). Discharge creatinine length stay also improved group. One-year patient survivals equivalent (95%) both Conclusions. early shortened compared Belzer MPS. Further improvement solutions conjunction shows promise improving outcomes after especially extended criteria kidneys.