Distribution of carcinoembryonic antigen-related cellular adhesion molecules in human gingiva

摘要: Carcinoembryonic antigen-related cellular adhesion molecules (CEACAMs) are glycoproteins produced in epithelial, endothelial, lymphoid, and myeloid cells. mediate cell-cell contact host-pathogen interactions. The aims of this study were to map the distribution examine regulation CEACAMs human gingival sites. Quantitative real-time PCR performed on biopsies from periodontitis sites revealed mRNA coding for CEACAM1, -5, -6, -7. Immunohistochemistry showed that not found oral epithelium, except CEACAM5 periodontitis. 1, 5, 6 present sulcular epithelium but healthy gingiva. In junctional all three gingiva, only CEACAM1 -6 detected. Staining was also seen inflammatory cell infiltrate No staining CEACAM7 found. Proinflammatory mediators, including lipopolysaccharide (LPS), tumour necrosis factor-α (TNF-α)/interleukin-1β (IL-1β), interferon-γ (IFN-γ), increased expression CEACAM6 mRNAs cultured keratinocytes. strongly up-regulated upon stimulation with lysophosphatidic acid. conclusion, different related specific This might reflect functional roles tissue.