摘要: Representations of cellular processes that can be used to compute their future behaviour would general scientific and practical value. But past attempts construct such representations have been disappointing. This is now changing. Increases in biological understanding combined with advances computational methods computer power make it possible foresee construction useful predictive simulations processes.
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Scott Cayley, Barbara A. Lewis, Harry J. Guttman, M.Thomas Record, Characterization of the cytoplasm of Escherichia coli K-12 as a function of external osmolarity. Implications for protein-DNA interactions in vivo. Journal of Molecular Biology. ,vol. 222, pp. 281- 300 ,(1991) , 10.1016/0022-2836(91)90212-O
Naama Barkai, Stanislas Leibler, Circadian clocks limited by noise Nature. ,vol. 403, pp. 267- 268 ,(2000) , 10.1038/35002258
Nay-Wei Soong, Laurel Nomura, Katja Pekrun, Margaret Reed, Liana Sheppard, Glenn Dawes, Willem P.C. Stemmer, Molecular breeding of viruses. Nature Genetics. ,vol. 25, pp. 436- 439 ,(2000) , 10.1038/78132
Michael B. Elowitz, Stanislas Leibler, A synthetic oscillatory network of transcriptional regulators Nature. ,vol. 403, pp. 335- 338 ,(2000) , 10.1038/35002125
Claudia Schmidt-Dannert, Daisuke Umeno, Frances H. Arnold, Molecular breeding of carotenoid biosynthetic pathways Nature Biotechnology. ,vol. 18, pp. 750- 753 ,(2000) , 10.1038/77319
S Hekimi, P Boutis, A Wong, Mutations in the Clk-1 Gene of Caenorhabditis Elegans Affect Developmental and Behavioral Timing Genetics. ,vol. 139, pp. 1247- 1259 ,(1995) , 10.1093/GENETICS/139.3.1247
Harley H. McAdams, Adam Arkin, John Ross, STOCHASTIC KINETIC ANALYSIS OF DEVELOPMENTAL PATHWAY BIFURCATION IN PHAGE LAMBDA -INFECTED ESCHERICHIA COLI CELLS Genetics. ,vol. 149, pp. 1633- 1648 ,(1998) , 10.1093/GENETICS/149.4.1633
S.A. Kauffman, Metabolic stability and epigenesis in randomly constructed genetic nets Journal of Theoretical Biology. ,vol. 22, pp. 437- 467 ,(1969) , 10.1016/0022-5193(69)90015-0
Steven B. Zimmerman, Stefan O. Trach, Estimation of macromolecule concentrations and excluded volume effects for the cytoplasm of Escherichia coli Journal of Molecular Biology. ,vol. 222, pp. 599- 620 ,(1991) , 10.1016/0022-2836(91)90499-V
H. H. McAdams, A. Arkin, Stochastic mechanisms in gene expression Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 814- 819 ,(1997) , 10.1073/PNAS.94.3.814