Antidepressants and the risk of falls among nursing home residents.
作者： Purushottam B. Thapa , Patricia Gideon , Terry W. Cost , Amanda B. Milam , Wayne A. Ray
DOI: 10.1056/NEJM199809243391303
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摘要: Background In nursing home residents, the use of tricyclic and other heterocyclic antidepressants is associated with an increased risk falls. The newer selective serotonin-reuptake–inhibitor are largely free side effects agents thought to cause falls so have been hypothesized be safer for those at high Methods We retrospectively identified inception cohort 2428 residents in Tennessee who were new users (665 subjects), serotonin-reuptake inhibitors (612 or trazodone (304 subjects) nonusers (847 subjects). ascertained number during therapy a similar follow-up period nonusers, then calculated rate ratios adjustments extensive set potential confounding factors. Results each type antidepressant had higher rates than adjusted 2.0 (95 pe...
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