Rabbits as a model for research into craniofacial distraction osteogenesis
作者： U.M. Djasim , J.M. Hekking-Weijma , E.B. Wolvius , J.W. van Neck , K.G.H. van der Wal
DOI: 10.1016/J.BJOMS.2008.04.002
关键词:
摘要: Various factors affect the choice of appropriate animal for craniofacial research. We have evaluated rabbit as a suitable research on distraction osteogenesis. describe our experience with housing and handling them, surgical experimental protocols, compare them other animals. introduce, use of, continuous hydraulic distractor nasal bones rabbit. Fifty-two skeletally mature New Zealand White rabbits were used. Forty-two 52 operations uneventful. Ten fifty-two developed complications, which two animal-related, eight distractor-related. During experiments animals stayed healthy, procedures well tolerated. Rabbits are excellent in biological Specifically, their easily accessible, size shape allow various commercially available custom-made distractors to be attached easily, care relatively simple inexpensive, harvesting tissue further analyses is no problem because skulls manageable compared laboratory
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