Involvement of lysosomal dysfunction in silver nanoparticle-induced cellular damage in A549 human lung alveolar epithelial cells
作者： Takamitsu Miyayama , Masato Matsuoka
DOI: 10.1186/S12995-016-0090-0
关键词:
摘要: Background While silver nanoparticles (AgNPs) are widely used in consumer and medical products, the mechanism by which AgNPs cause pulmonary cytotoxicity is not clear. AgNP agglomerates found endo-lysosomal structures within cytoplasm of treated cells. In this study, functional role lysosomes AgNP-induced cellular damage was examined A549 human lung alveolar epithelial We evaluated intracellular distribution AgNPs, lysosomal pH, viability, Ag dissolution, metallothionein (MT) mRNA levels AgNP-exposed cells that were with bafilomycin A1, acidification inhibitor.
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