Pregnancy outcomes in women with epilepsy: A systematic review and meta-analysis of published pregnancy registries and cohorts
作者： Kimford Meador , Matthew W. Reynolds , Sheila Crean , Kyle Fahrbach , Corey Probst
DOI: 10.1016/J.EPLEPSYRES.2008.04.022
关键词:
摘要: Summary Purpose To conduct a systematic review and meta-analysis to quantify the incidence of congenital malformations (CMs) other pregnancy outcomes as function in utero anti-epileptic drug (AED) exposure. Methods We performed literature identify all published registries cohort studies births from pregnant women with epilepsy (WWE) that reported CMs. Overall incidences were calculated using random effects model. Results The included 59 met inclusion/exclusion criteria, involving 65,533 pregnancies WWE 1,817,024 healthy women. CM [7.08%; 95% CIs 5.62, 8.54] was higher than [2.28%; 1.46, 3.10]. Incidence highest for AED polytherapy [16.78%; 0.51, 33.05]. valproate, which 10.73% [CIs 8.16, 13.29] valproate monotherapy. Conclusions this suggest overall CMs children born is approximately threefold risk elevated monotherapy further compared without epilepsy. significantly exposed 2 or more drugs when combination phenobarital, phenytoin, valproate. Further research needed delineate specific each individual determine underlying mechanisms including genetic factors.
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