Local and Systemic Effects on the Epidermal Melanocyte Population in UV-irradiated Mouse Skin

摘要: Local and systemic effects of repeated UVB irradiation on the epidermal melanocytes have been studied in C57B1 mice. A daily dose 0.1 joule/cm 2 for 10days induced a 4-fold increase melanocyte population irradiated right ear. During first weeks after period, there was gradual number also shielded left ear, up to about 3 times age control values. Thereafter, density slowly decreased both ears, but it remained well above original values as late 20weeks irradiation. Thus, short period induces long-lasting skin areas, covered regions. It is suggested that ear initiated by one or more factors originating from skin. Such may be involved regulation balanced over entire body surface.