Role of the Middle T: pp60c-src Complex in Cellular Transformation by Polyoma Virus

摘要: The polyoma virus of mice has been extensively studied over the last two decades, primarily because its ability to induce neoplastic transformation mammalian cells in vivo and vitro (for reviews, see Griffin Dilworth 1983; Smith Ely 1983). small size viral genome ease with which it can be manipulated make an attractive system study mechanisms whereby normal cell growth is transformed a state uncontrolled proliferation that culminates neoplasia. early region maintain encodes three proteins, designated large T, middle T T. protein by itself sufficient transform established (Treisman et al. 1981), although portion gene and, under certain circumstances, are also required primary (Rassoulzadegan 1982; article Mougneau Cuzin, this Vol.). Here we discuss activities associated possible action oncogene.