Bovine viral diarrhoea virus and bovine herpesvirus-1 prime uninfected macrophages for lipopolysaccharide-triggered apoptosis by interferon-dependent and -independent pathways.

摘要: The flavivirus bovine viral diarrhoea (BVD) virus exists in two biotypes, cytopathic (cp) and non-cytopathic (ncp), defined by their effect on cultured cells. Cp BVD virus-infected cells undergo apoptosis may promote uninfected an indirect mechanism. Macrophages (Mϕ) infected with cp, but not ncp, release a factor(s) the supernatant capable of priming Mϕ for activation-induced response to lipopolysaccharide. A possible role interferon (IFN) type I was suggested previously observation that this cytokine primed present supernatants virus. Here, both wider range cp herpesvirus-1 are shown contain such activity. Two lines evidence indicate factors addition IFN prime apoptosis. First, contained much less than is required Second, whereas antiviral activity neutralized vaccinia virus-encoded receptor, B18R, capacity unaffected treatment. apparent molecular mass between 30 100 kDa. Priming add new facet pathogenesis contribute formation lesions related directly replication.