Synthesis and spectroscopic analysis of a stereoisomer library of the phytophthora mating hormone α1 and derived bis-Mosher esters.
作者： Reena Bajpai , Dennis P. Curran
DOI: 10.1021/JA2082679
关键词:
摘要: Fluorous mixture synthesis provided all eight diastereomers of the phytophthora hormone α1 with R configuration at C11 as individual samples after demixing and detagging. The library possible bis-Mosher esters (16) was then made by esterification. Complete sets (1)H, (13)C, (for Mosher esters) (19)F NMR spectra were recorded, assigned, compared each other published spectra. Not are unique, (1)H most information. previous assignment natural sample an "all-R" stereoisomer mixed its 3S-epimer confirmed.
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