inhibition of human platelet monoamine oxidase by phenothiazine derivatives
作者： Osamu Suzuki , Hiroshi Seno , Takeshi Kumazawa
DOI: 10.1016/0024-3205(88)90127-0
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摘要: Abstract Nineteen phenothiazines were tested for in vitro inhibition of human platelet type B monoamine oxidase (MAO). The potency was highly dependent on structures their side chains. most potent drugs with (hydroxyethyl-piperazinyl)propyl chains followed decreasing order by those (N-methylpiperazinyl)propyl, (2-dimethylamino-2-methyl)ethyl and 3-dimethylaminopropyl Kinetic analyses carried out promazine, promethazine, perazine perphenazine as representatives each group; the four showed competitive inhibition, K i values 124, 31.4, 19.2 22.6 μM, respectively.
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