Steroid Response in Stable Chronic Obstructive Pulmonary Disease

作者: L. A. MENDELLA

DOI: 10.7326/0003-4819-96-1-17

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摘要: We compared a 2-week course of 32 mg/d methylprednisolone with placebo in double-blind crossover trial 46 well-characterized patients stable chronic obstructive pulmonary disease. Placebo and steroid trials were separated by 2 weeks when no tablets given. Response was assessed measuring forced expiratory volume 1 second (FEV1.0). responses normally distributed (mean, 0.8% change FEV1.0; range, -30% to 33%). Six showed greater than 50% increase FEV1.0 response steroid; seventh 36% an eighth, 29% increase. Because these the group as whole significantly after placebo. The eight responders did not differ from nonresponders age, sex, smoking history, or duration intensity symptoms including wheeze. Baseline lung function eosinophilia blood sputum between two groups. Patients who responded steroids also inhaled beta agonists: Acute bronchodilator averaged 25% 13% nonresponders, difference that statistically significant although there overlap

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