Crystal Structure of Sphingosine Kinase 1 with Pf-543.
作者： Jing Wang , Stefan Knapp , Nigel J. Pyne , Susan Pyne , Jonathan M. Elkins
DOI: 10.1021/ML5004074
关键词:
摘要: … , its (R)-2-(hydroxymethyl)-pyrrolidine head group would need to rotate ∼180 to bring the primary hydroxyl into a position equivalent to that of the lipid primary hydroxyl in PDB ID 3VZB …
strath.ac.uk
rcsb.org
acs.org参考文章(37)
Jerold Chun, Volker Brinkmann, A Mechanistically Novel, First Oral Therapy for Multiple Sclerosis: The Development of Fingolimod (FTY720, Gilenya) Discovery Medicine. ,vol. 12, pp. 213- 228 ,(2011)
Jeremy A. Hengst, XuJun Wang, Ugir H. Sk, Arun K. Sharma, Shantu Amin, Jong K. Yun, Development of a sphingosine kinase 1 specific small-molecule inhibitor. Bioorganic & Medicinal Chemistry Letters. ,vol. 20, pp. 7498- 7502 ,(2010) , 10.1016/J.BMCL.2010.10.005
Shinji Yokota, Yuki Taniguchi, Akio Kihara, Susumu Mitsutake, Yasuyuki Igarashi, Asp177 in C4 domain of mouse sphingosine kinase 1a is important for the sphingosine recognition FEBS Letters. ,vol. 578, pp. 106- 110 ,(2004) , 10.1016/J.FEBSLET.2004.10.081
Ana Olivera, Takafumi Kohama, Zhenxing Tu, Sheldon Milstien, Sarah Spiegel, Purification and Characterization of Rat Kidney Sphingosine Kinase Journal of Biological Chemistry. ,vol. 273, pp. 12576- 12583 ,(1998) , 10.1074/JBC.273.20.12576
Nigel J. Pyne, Susan Pyne, Sphingosine 1-Phosphate Is a Missing Link between Chronic Inflammation and Colon Cancer Cancer Cell. ,vol. 23, pp. 5- 7 ,(2013) , 10.1016/J.CCR.2012.12.005
Nigel J. Pyne, Susan Pyne, Sphingosine 1-phosphate and cancer. Nature Reviews Cancer. ,vol. 10, pp. 489- 503 ,(2010) , 10.1038/NRC2875
Wen-Qi Lai, W.S. Fred Wong, Bernard P. Leung, Sphingosine kinase and sphingosine 1-phosphate in asthma. Bioscience Reports. ,vol. 31, pp. 145- 150 ,(2011) , 10.1042/BSR20100087
Stuart M. PITSON, Richard J. D'ANDREA, Lucianne VANDELEUR, Paul A. B. MORETTI, Pu XIA, Jennifer R. GAMBLE, Mathew A. VADAS, Binks W. WATTENBERG, Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes. Biochemical Journal. ,vol. 350, pp. 429- 441 ,(2000) , 10.1042/BJ3500429
Hong Liu, Masako Sugiura, Victor E. Nava, Lisa C. Edsall, Keita Kono, Samantha Poulton, Sheldon Milstien, Takafumi Kohama, Sarah Spiegel, Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform Journal of Biological Chemistry. ,vol. 275, pp. 19513- 19520 ,(2000) , 10.1074/JBC.M002759200
N. C. Hait, J. Allegood, M. Maceyka, G. M. Strub, K. B. Harikumar, S. K. Singh, C. Luo, R. Marmorstein, T. Kordula, S. Milstien, S. Spiegel, Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate Science. ,vol. 325, pp. 1254- 1257 ,(2009) , 10.1126/SCIENCE.1176709