Fatal sepsis in a patient with rheumatoid arthritis treated with etanercept.

摘要: Patients with long-standing, severe, erosive rheumatoid arthritis who have extra-articular manifestations and undergone joint replacement surgery are at increased risk for serious infection premature mortality. New therapies, including cytokine antagonists, hold great promise improving the course of arthritis. However, they powerful anti-inflammatory effects that may mask symptoms infection. We report a case fatal pneumococcal sepsis occurring in 37-year-old woman treated tumor necrosis factor antagonist etanercept suggest management strategies early detection this complication.