Using proportions of free to total prostate-specific antigen, age, and total prostate-specific antigen to predict the probability of prostate cancer

摘要: Abstract Objectives This study was undertaken to define the probability of prostate cancer as a function proportion free total prostate-specific antigen (FTPSA), PSA, and age for those patients with PSA levels between 2.5 20.0 ng/mL. Methods Prebiopsy serums were obtained from 428 untreated (165 malignant, 263 benign) who had undergone sextant six-core biopsy. Each patient no prior history prebiopsy value Total determined using PA immunoassay performed on TOSOH AIA-1200 automated instrument. Free monoclonal-polyclonal antibody sandwich radioimmunoassay. Results In men values ng/mL, FTPSA significantly differentiated benign malignant histologic states. Log linear modeling indicated distinct differences in risk FTPSA, age. The highest observed greater than 70 years less 7% more 10.0 Conversely, lowest 60 25% 4 Conclusions that will be found biopsy has marked gradient is associated age, FTPSA. extreme ends are diagnostic prostatic disease, respectively.