mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

作者: Masahiro Morita , Simon-Pierre Gravel , Valérie Chénard , Kristina Sikström , Liang Zheng

DOI: 10.1016/J.CMET.2013.10.001

关键词:

摘要: … The mechanistic/mammalian target of … controls mitochondrial activity and biogenesis by selectively promoting translation of nucleus-encoded mitochondria-related mRNAs via inhibition …

参考文章(65)
John T. Cunningham, Joseph T. Rodgers, Daniel H. Arlow, Francisca Vazquez, Vamsi K. Mootha, Pere Puigserver, mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex Nature. ,vol. 450, pp. 736- 740 ,(2007) , 10.1038/NATURE06322
D. F. Rolfe, G. C. Brown, Cellular energy utilization and molecular origin of standard metabolic rate in mammals Physiological Reviews. ,vol. 77, pp. 731- 758 ,(1997) , 10.1152/PHYSREV.1997.77.3.731
Jessica L. Yecies, Brendan D. Manning, mTOR links oncogenic signaling to tumor cell metabolism Journal of Molecular Medicine. ,vol. 89, pp. 221- 228 ,(2011) , 10.1007/S00109-011-0726-6
Brian M. Zid, Aric N. Rogers, Subhash D. Katewa, Misha A. Vargas, Marysia C. Kolipinski, Tony Au Lu, Seymour Benzer, Pankaj Kapahi, 4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila Cell. ,vol. 139, pp. 149- 160 ,(2009) , 10.1016/J.CELL.2009.07.034
N. V. Dorrello, A. Peschiaroli, D. Guardavaccaro, N. H. Colburn, N. E. Sherman, M. Pagano, S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth Science. ,vol. 314, pp. 467- 471 ,(2006) , 10.1126/SCIENCE.1130276
Jan Hoffmann, Lucie Sokolova, Laura Preiss, David B. Hicks, Terry A. Krulwich, Nina Morgner, Ilka Wittig, Hermann Schägger, Thomas Meier, Bernd Brutschy, ATP synthases: cellular nanomotors characterized by LILBID mass spectrometry Physical Chemistry Chemical Physics. ,vol. 12, pp. 13375- 13382 ,(2010) , 10.1039/C0CP00733A
Andrew C. Hsieh, Yi Liu, Merritt P. Edlind, Nicholas T. Ingolia, Matthew R. Janes, Annie Sher, Evan Y. Shi, Craig R. Stumpf, Carly Christensen, Michael J. Bonham, Shunyou Wang, Pingda Ren, Michael Martin, Katti Jessen, Morris E. Feldman, Jonathan S. Weissman, Kevan M. Shokat, Christian Rommel, Davide Ruggero, The translational landscape of mTOR signalling steers cancer initiation and metastasis Nature. ,vol. 485, pp. 55- 61 ,(2012) , 10.1038/NATURE10912
Arnim Pause, Graham J. Belsham, Anne-Claude Gingras, Olivier Donzé, Tai-An Lin, John C. Lawrence, Nahum Sonenberg, Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function Nature. ,vol. 371, pp. 762- 767 ,(1994) , 10.1038/371762A0
Katrin Düvel, Jessica L. Yecies, Suchithra Menon, Pichai Raman, Alex I. Lipovsky, Amanda L. Souza, Ellen Triantafellow, Qicheng Ma, Regina Gorski, Stephen Cleaver, Matthew G. Vander Heiden, Jeffrey P. MacKeigan, Peter M. Finan, Clary B. Clish, Leon O. Murphy, Brendan D. Manning, Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1 Molecular Cell. ,vol. 39, pp. 171- 183 ,(2010) , 10.1016/J.MOLCEL.2010.06.022