Multimorbidity in women with and without osteoporosis: results from a large US retrospective cohort study 2004–2009

摘要: To determine the incidence of comorbidities in women with and without osteoporosis, rates per 1,000 person-years were calculated using electronic health records from an integrated healthcare system. The overall comorbidity burden service utilization greater osteoporosis than controls. This retrospective cohort study describes array (OP). Using system, we identified 22,414 aged 55–89 years OP age-matched controls OP. Incidence (IRs) (P-Y) 95 % confidence intervals (CI) estimated. Women had significantly more comorbidities, medications, hospitalizations, outpatient visits Most cardiac 20–25 % lower control cohort. Hypertension largest rate difference; IR was 42.0 P-Y (95 % CI 40.2–44.0) compared to 94.0 90.7–97.4) Rates for cerebrovascular disease similar both cohorts at 26 P-Y. Bronchitis, sinusitis, cystitis each 55 cohort, whereas they ranged 28 34 decreased ovarian, uterine, colorectal, liver cancers increased lung cancer, breast multiple myeloma, non-OP Falls, depression, vision, musculoskeletal issues higher demonstrates high knowledge may help guide clinical management this population aid interpretation adverse events randomized trials therapies.