The effect of dinitrosyl iron complexes with glutathione and S-nitrosoglutathione on the development of experimental endometriosis in rats: A comparative studies
作者： Evgeniya N. Burgova , Nikolai А. Tkachev , Oksana V. Paklina , Vasak D. Mikoyan , Leila V. Adamyan
DOI: 10.1016/J.EJPHAR.2014.07.017
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摘要: Abstract It has been established that intraperitoneal bolus administration of S-nitrosoglutathione (GS-NO) (12.5 μmoles/kg; 10 injections in days), beginning with day 4 after transplantation two 2-mm autologous fragments endometrial tissue onto the inner surface abdominal wall rats surgically induced (experimenta) endometriosis failed to prevent further growth endometrioid (EMT) and additive tumors, while treatment animals dinitrosyl iron complexes (DNIC) glutathione (12.5 μmoles/kg, days) suppressed tumor virtually completely. The histological analysis EMT samples GS-NO-treated revealed pathological changes characteristic control (non-treated GS-NO or DNIC) experimental endometriosis. EPR studies presence active form ribonucleotide reductase, a specific marker for rapidly proliferating both animals. Noteworthy, small-size adjacent tissues DNIC-treated reductase were not found.
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