Hepatitis B virus and hepatitis C virus play different prognostic roles in intrahepatic cholangiocarcinoma: A meta-analysis

摘要: AIM: To identify the prognostic value of hepatitis B virus (HBV) and C (HCV) infections in patients with intrahepatic cholangiocarcinoma. METHODS: A search was performed for relevant publications PubMed, EMBASE Web Science databases. The pooled effects were calculated from available information to relationship between HBV or HCV infection prognosis clinicopathological features. χ2 I2 tests used evaluate heterogeneity studies. Pooled hazard ratios (HRs) 95% confidence intervals (CIs) by a fixed-effects model, if no existed. If there heterogeneity, random-effects model applied. RESULTS: In total, 14 studies involving 2842 cases enrolled this meta-analysis. presented better overall disease-free survival, HRs significant at 0.76 (95%CI: 0.70-0.83) 0.78 0.66-0.94), respectively. Additionally, our study revealed that correlated shortened survival comparison control group (HR = 2.64, 95%CI: 1.77-3.93). We also found occurred more frequently male [odds ratio (OR) 1.91, 1.06-3.44] higher levels serum aspartate transaminase (AST) alpha-fetoprotein (AFP) (OR 1.93, 1.11-3.35; OR 3.86, 2.58-5.78) lower level carbohydrate antigen 19-9 (CA19-9) 0.47, 0.34-0.65). Moreover, associated cirrhosis 6.44, 4.33-9.56), proportion capsule formation 6.04, 3.56-10.26), rate lymph node metastasis 0.39, 0.25-0.58). No publication bias seen any studies. CONCLUSION: may indicate favorable cholangiocarcinoma, while suggests poor prognosis.