Hypolipidaemic and antioxidant capacities of polysaccharides obtained from Laminaria japonica by different extraction media in diet‐induced mouse model
作者： Yujing Yao , Huan Xiang , Lijun You , Chun Cui , Dongxiao Sun-Waterhouse
DOI: 10.1111/IJFS.13508
关键词:
摘要: Summary This study shows the industrial feasibility of using aqueous methods to produce antioxidative and hypolipidaemic polysaccharides from Laminaria japonica (LJP). Comparison was firstly made among prepared different extraction media, that is water alone (LJPW) citric acid (LJPC), sulphuric acid, hydrochloric phosphoric acid. LJPC enabled highest extract yield (~11% dry weight), bile salt adsorption rate (~59% ABTS radical scavenging activity (IC50 value 1.06 mg mL−1) ORAC antioxidant (341.87 μmol Trolox g−1). In animal trial diet-induced high-fat mice, oral administration LJP produced with (LJPC) at a high dose (200 mg kg−1 body mass per day) significantly higher serum HDL-C, lower LDL-C/HDL-C unaltered LDL-C, whilst medium (100 mg kg−1 body decreased LDL-C. Administration lowered Therefore, may provide dose-dependent pharmacological therapeutic effects combat atherosclerosis through their hyperlipidaemic properties.
sci-hub.se 参考文章(39)
Z Ďuračková, Some current insights into oxidative stress. Physiological Research. ,vol. 59, pp. 459- 469 ,(2010) , 10.33549/PHYSIOLRES.931844
Ning Jiang, Shuangjian Zhang, Jing Zhu, Jing Shang, Xiangdong Gao, Hypoglycemic, Hypolipidemic and Antioxidant Effects of Peptides from Red Deer Antlers in Streptozotocin-Induced Diabetic Mice Tohoku Journal of Experimental Medicine. ,vol. 236, pp. 71- 79 ,(2015) , 10.1620/TJEM.236.71
B.S. Rangika, P.D. Dayananda, D.C. Peiris, Hypoglycemic and hypolipidemic activities of aqueous extract of flowers from Nycantus arbor-tristis L. in male mice. BMC Complementary and Alternative Medicine. ,vol. 15, pp. 289- 289 ,(2015) , 10.1186/S12906-015-0807-0
Michel. DuBois, K. A. Gilles, J. K. Hamilton, P. A. Rebers, Fred. Smith, Colorimetric Method for Determination of Sugars and Related Substances Analytical Chemistry. ,vol. 28, pp. 350- 356 ,(1956) , 10.1021/AC60111A017
LI TIAN, XIJIE YU, Lipid metabolism disorders and bone dysfunction-interrelated and mutually regulated (Review) Molecular Medicine Reports. ,vol. 12, pp. 783- 794 ,(2015) , 10.3892/MMR.2015.3472
Ling-Jun Zeng, Dan Chen, Qing-De Huang, Qun Huang, Yun-Fang Lian, Wei-Wei Cai, Hua-Ping Zeng, Yi-Li Lin, Isolation of a new flavanone from Daidai fruit and hypolipidemic activity of total flavonoids extracts Natural Product Research. ,vol. 29, pp. 1521- 1528 ,(2015) , 10.1080/14786419.2014.992344
Jing Li, Shengyong Wang, Xiaomei Yang, Guangbao Pang, Hua Zheng, Bin Shen, Guanhong Li, Dianchun Shi, Jienian Wang, Liaoyun Feng, Mulan Li, Wuying Wei, Wu Qin, Lu Xie, Effect of sulfated polysaccharides from Laminaria japonica on vascular endothelial cells in psychological stress rats Journal of Ethnopharmacology. ,vol. 151, pp. 601- 608 ,(2014) , 10.1016/J.JEP.2013.11.014
Ozcan Erel, A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation Clinical Biochemistry. ,vol. 37, pp. 277- 285 ,(2004) , 10.1016/J.CLINBIOCHEM.2003.11.015
Monique Gabriela das Chagas Faustino Alves, Celina Maria Pinto G Dore, Allisson Jhonatan G Castro, Marília Silva do Nascimento, Ana Katarina M Cruz, Eliane M Soriano, Norma M Barros Benevides, Edda Lisboa Leite, None, Antioxidant, cytotoxic and hemolytic effects of sulfated galactans from edible red alga Hypnea musciformis Journal of Applied Phycology. ,vol. 24, pp. 1217- 1227 ,(2012) , 10.1007/S10811-011-9763-3
Navindra P. Seeram, Susanne M. Henning, Yantao Niu, Rupo Lee, H. Samuel Scheuller, David Heber, Catechin and Caffeine Content of Green Tea Dietary Supplements and Correlation with Antioxidant Capacity Journal of Agricultural and Food Chemistry. ,vol. 54, pp. 1599- 1603 ,(2006) , 10.1021/JF052857R