Hypoglycemic and hypolipidemic activities of aqueous extract of flowers from Nycantus arbor-tristis L. in male mice.

摘要: Boiled aqueous extract of flowers (AEF) from Nyctanthes arbor-tristis L. are used in Sri Lankan traditional Ayruvedic Medicine to manage diabetes mellitus. AEF has widely been as a folk medicine for the treatment various ailments due its therapeutic activity. However, little is known concerning activity well underline mechanisms and safety. Diabetes increase low-density cholesterol decrease high-density thus triggering coronary diseases. Hence, primary objective present study investigate hypoglycemic hypolipidemic activities AEF. was prepared male mice (n = 9 group) were gavaged either with 250, 500 750 mg/kg or distilled water (DW). Subsequently, fasting random blood glucose concentrations determined. To actions AEF, animals orally administered 500 mg/kg vehicle (DW) tolerance performed before after challenge. For further studies, vitro alpha-amylase assay absorption gastrointestinal tract using extract. Additionally, glycogen content liver skeletal muscles, complete lipid profile assay, toxicological biochemical parameters conducted chronic study. Five hundred mg/kg significantly (p < 0.01) reduced levels respectively by 49 39 % at 4 h post-treatment, while also decreased level (p <0.01) 32 post-treatment. inhibited 85 intestine increased diaphragm uptake 64 %. The exhibited inhibition (16.66 %) enzyme It total (by 44.8 %), triglyceride 53 57 lipoprotein cholesterol. Treatment did not induce any overt signs toxicity hepatotoxicity. Results indicated that possess hypolipdemic properties. Therefore, could be an alternative management