An updated meta-analysis of transforming growth factor-β1 gene: three polymorphisms with gastric cancer
作者： Wei-wei Chang , Liu Zhang , Hong Su , Ying-shui Yao
DOI: 10.1007/S13277-013-1408-5
关键词:
摘要: To derive a more precise estimation of the relationship between TGF-β1 polymorphisms and gastric cancer (GC) risk, we conducted meta-analysis all available case–control studies relating C-509 T, T869C, G 915C gene to risk developing GC. The effect summary odds ratio (OR) 95 % confidence intervals (CIs) were obtained. Funnel plots Egger's test used estimate publication bias. Finally, 11 included in final meta-analysis. With respect T polymorphism, it was found that significantly increased GC associated with TT genotype recessive genetic model overall analysis (TT vs. CC + CT: OR = 1.23, CI 1.09–1.38, Pheterogeneity 0.13) Asian population 1.24, 1.10–1.39, 0.18). T869C G915C polymorphisms, no significant association demonstrated subgroup analyses according ethnicity for models. This suggested allele 509C/T polymorphism is probably susceptibility factor
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