Association ofTGF-β1−509C/T, +869T/C, and +915G/C polymorphisms with periodontitis susceptibility
作者： J Huang , C Ding , X Chen , R He , N Chen
DOI: 10.1111/ODI.12297
关键词:
摘要: Objectives To investigate the potential association of TGF-β1 −509C/T (rs1800469), +869T/C (rs1800470), and +915G/C (rs1800471) polymorphisms with susceptibility to periodontitis. Materials Methods Several electronic databases were searched for eligible articles. Odds ratios (ORs) along their 95% confidence intervals (CIs) calculated assess strength relationship between periodontitis risk. Results Eleven studies without any language restriction. Pooled estimates showed that polymorphism was associated decreased risk periodontitis. Subgroup analysis revealed T allele chronic (CP) in Asians (T vs C allele: OR = 0.81, CI = 0.69–0.97, Pheterogeneity = 0.25). Furthermore, CC genotype might be elevated CP Caucasians (CC GG: OR = 9.14, CI = 1.01–82.50, Pheterogeneity = 0.49). Concerning polymorphism, no evidence significant identified. Conclusion This meta-analysis suggested Asians, while contribute increased Caucasians. Replication our results independent large populations are necessary validate this diverse populations.
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