Association of interleukin-1 receptor antagonist +2018 gene polymorphism with Japanese chronic periodontitis patients using a novel genotyping method.

摘要: Genetic variants at multiple loci have been shown to be associated with periodontitis risk. In this study, we focused on nine functional gene polymorphisms encoding immunoregulation-related molecules such as cytokines (interleukin-1 (IL-1), transforming growth factor-beta1 (TGF-beta1)) and cell surface receptors (immunoglobulin G A Fc (Fc gamma R alpha R)). total, 113 Japanese patients chronic (CP) 108 race-matched healthy controls were genotyped the modified serial invasive signal amplification reaction. There was a significant difference in distribution of IL-1 receptor antagonist (RN) +2018 T/C allele between patient control groups, enrichment C (P = 0.021, odds ratio 0.38). An increased frequency haplotype comprising IL-1A +4845 G, IL-1B -31 C, IL-1RN observed 0.004). Moreover, multivariate logistic regression analysis revealed that subjects less likely CP 0.016, 0.29). These findings document association reduced susceptibility Japanese.