Optimized peptide based inhibitors targeting the dihydrofolate reductase pathway in cancer.
作者： Amrinder Singh , Neha Deshpande , Nilkamal Pramanik , Siddharth Jhunjhunwala , Annapoorni Rangarajan
DOI: 10.1038/S41598-018-21435-5
关键词:
摘要: … based hDHFR inhibitors designed on the basis of structural analysis of dihydrofolate reductase (DHFR). A … All of the purified peptides were obtained as white powder after lyophilization. …
nature.com
harvard.edu
sci-hub.se 参考文章(29)
Ghada S. Hassan, Shahenda M. El-Messery, Fatmah A.M. Al-Omary, Sarah T. Al-Rashood, Marwa I. Shabayek, Yasmin S. Abulfadl, El-Sayed E. Habib, Salwa M. El-Hallouty, Walid Fayad, Khaled M. Mohamed, Bassem S. El-Menshawi, Hussein I. El-Subbagh, Nonclassical antifolates, part 4. 5-(2-Aminothiazol-4-yl)-4-phenyl-4H-1,2,4-triazole-3-thiols as a new class of DHFR inhibitors: Synthesis, biological evaluation and molecular modeling study European Journal of Medicinal Chemistry. ,vol. 66, pp. 135- 145 ,(2013) , 10.1016/J.EJMECH.2013.05.039
Jyothi Thundimadathil, Cancer Treatment Using Peptides: Current Therapies and Future Prospects Journal of Amino Acids. ,vol. 2012, pp. 967347- 967347 ,(2012) , 10.1155/2012/967347
E Schneider, D D Ross, M Rhee, K Rohde, E L Volk, J J McGuire, L A Doyle, Methotrexate Cross-Resistance in a Mitoxantrone-selected Multidrug-resistant MCF7 Breast Cancer Cell Line Is Attributable to Enhanced Energy-dependent Drug Efflux Cancer Research. ,vol. 60, pp. 3514- 3521 ,(2000)
Nicolas Bertrand, Jun Wu, Xiaoyang Xu, Nazila Kamaly, Omid C. Farokhzad, Cancer Nanotechnology: The impact of passive and active targeting in the era of modern cancer biology Advanced Drug Delivery Reviews. ,vol. 66, pp. 2- 25 ,(2014) , 10.1016/J.ADDR.2013.11.009
L. L. Baggio, Q. Huang, T. J. Brown, D. J. Drucker, A Recombinant Human Glucagon-Like Peptide (GLP)-1–Albumin Protein (Albugon) Mimics Peptidergic Activation of GLP-1 Receptor–Dependent Pathways Coupled With Satiety, Gastrointestinal Motility, and Glucose Homeostasis Diabetes. ,vol. 53, pp. 2492- 2500 ,(2004) , 10.2337/DIABETES.53.9.2492
B. E. I. Ramakers, J. C. M. van Hest, D. W. P. M. Löwik, Molecular tools for the construction of peptide-based materials Chemical Society Reviews. ,vol. 43, pp. 2743- 2756 ,(2014) , 10.1039/C3CS60362H
Cornelia Loos, Tatiana Syrovets, Anna Musyanovych, Volker Mailänder, Katharina Landfester, G Ulrich Nienhaus, Thomas Simmet, Functionalized polystyrene nanoparticles as a platform for studying bio–nano interactions Beilstein Journal of Nanotechnology. ,vol. 5, pp. 2403- 2412 ,(2014) , 10.3762/BJNANO.5.250
Antoine Henninot, James C. Collins, John M. Nuss, The Current State of Peptide Drug Discovery: Back to the Future? Journal of Medicinal Chemistry. ,vol. 61, pp. 1382- 1414 ,(2017) , 10.1021/ACS.JMEDCHEM.7B00318
Derek B. Oien, Gonzalo A. Carrasco, Jackob Moskovitz, Erratum to “Decreased Phosphorylation and Increased Methionine Oxidation of -Synuclein in the Methionine Sulfoxide Reductase A Knockout Mouse” Journal of Amino Acids. ,vol. 2012, pp. 1- 1 ,(2012) , 10.1155/2012/415713
Liv Tone Eliassen, Øystein Rekdal, Baldur Sveinbjørnsson, John S Svendsen, Lars H Vorland, Gerd Berge, Evidence for a direct antitumor mechanism of action of bovine lactoferricin. Anticancer Research. ,vol. 22, pp. 2703- 2710 ,(2002)