Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure.

摘要: Pharmacotherapy during pregnancy is often inevitable for medical treatment of the mother, fetus or both. The knowledge drug transport across placenta is, therefore, an important topic to bear in mind when deciding pregnant women. Several transporters ABC and SLC families have been discovered placenta, such as P-glycoprotein, breast cancer resistance protein, organic anion/cation transporters. It thus evident that passage drugs can no longer be predicted simply on basis their physical-chemical properties. Functional expression placental trophoblast possibility drug-drug interactions must considered optimize pharmacotherapy pregnancy. In this review we summarize current function trophoblast. Furthermore, put data into context with conditions require maternal and/or fetal pregnancy, gestational diabetes, HIV infection, arrhythmias epilepsy. Proper understanding role should great interest not only clinicians but also pharmaceutical industry future design development control degree exposure.