Associations between ABCG2 gene polymorphisms and isolated septal defects in a Han Chinese population.
作者： Chuan Wang , Liang Xie , Huaying Li , Yifei Li , Dezhi Mu
关键词: Genetics 、 Allele frequency 、 Biology 、 Genotyping 、 Odds ratio 、 Case-control study 、 Genotype 、 Abcg2 、 ABCG2 Gene 、 Placenta
摘要: Breast cancer resistance protein (BCRP) in the placenta, encoded by ABCG2 gene humans, plays an essential role regulating fetal exposure to toxicants and maintenance of cellular folic acid homeostasis. This study aimed at exploring associations between 421C>A 34G>A polymorphisms within children isolated septal defects a Han Chinese population. An age- gender-matched case-control involving 210 pairs was conducted. Genotyping performed sequencing. Forty-six placental tissues umbilical cords from healthy mothers with uncomplicated pregnancy were collected investigate impact these two on transcription translation activities gene. The results showed that there no differences genotype distributions allele frequencies polymorphism. For polymorphism, more cases carriers GA/AA genotypes (adjusted odds ratio [...
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