Regulation of drug transporter expression and function in the placenta

摘要: Introduction: Medication of pregnant women is increasingly common in developed countries. Several placental drug transporters have been shown to transfer their substrates from the trophoblast back maternal circulation, thus hindering transplacental passage xenobiotics and protecting fetus. However, expression activity transporter proteins placenta vary during gestation are tightly regulated by many factors. In addition, function can be compromised pathological conditions and/or drug–drug interactions.Areas covered: This article reviews current knowledge on transporters, effects pharmacokinetics regulatory mechanisms that control activity. Transcriptional, genetic epigenetic regulation interactions modulate described. Physiological factors affect f...