Association between maternal occupational exposure to organic solvents and congenital heart defects, National Birth Defects Prevention Study, 1997–2002

作者: Suzanne M Gilboa , Tania A Desrosiers , Christina Lawson , Philip J Lupo , Tiffany J Riehle-Colarusso

DOI: 10.1136/OEMED-2011-100536

关键词:

摘要: Objective To examine the relation between congenital heart defects (CHDs) in offspring and estimated maternal occupational exposure to chlorinated solvents, aromatic solvents Stoddard solvent during period from 1 month before conception through first trimester. Methods The study population included mothers of infants with simple isolated CHDs control who delivered 1997 2002 participated National Birth Defects Prevention Study. Two methods assess were employed: an expert consensus-based approach a literature-based approach. Multiple logistic regression was used calculate adjusted ORs 95% CIs for association classes CHDs. Results 2951 2047 CHD case included. Using approach, associations observed any perimembranous ventricular septal (OR 1.6, CI 1.0 2.6 OR 1.7, 2.8, respectively). for: aortic stenosis 2.1, 1.1 4.1) d-transposition great arteries 2.0, 4.2), right outflow tract obstruction 1.9, 3.3) pulmonary valve 3.8). Conclusions authors found evidence several types These results should be interpreted light potential misclassification exposure.

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