Fetoprotective activity of breast cancer resistance protein (BCRP, ABCG2): expression and function throughout pregnancy

摘要: The medical treatment of pregnant women, as well their fetuses, has become a common clinical practice in developed countries. Therefore, detailed knowledge maternofetal pharmacokinetics, including the role drug-efflux transporters fetoplacental unit, is crucial to optimize drug choice and dosage schemes avoid or exploit possible drug-drug interactions on placental order assure appropriate levels mother and/or fetus. Breast cancer resistance protein (BCRP, ABCG2) most recent member ATP-binding cassette that been associated with chemotherapy. Importantly, ABCG2 also localized various normal tissues, affecting pharmacokinetics several xenobiotics number physiological substances. Extensive expression tissue barriers, such blood-brain barrier, intestine, testis, placenta, suggests plays an important protection sensit...